An ongoing concern of intervention research in the area of adolescent substance use and abuse is the varying impact of interventions on individuals. To understand why intervention effects vary, it is critical to broaden the scope of inquiry to include gene-by-environment (G-E) interplay, including but not limited to the moderation of intervention impact by specific genes. In this study we are examining G-E interplay by adding a large panel of candidate genes implicated in substance use to the PROSPER study, a prospective cohort study of preventative interventions’ impact on adolescent substance use. PROSPER provides specific and repeated annual assessments of substance use and contributing environmental factors from 6th grade through early adulthood. Our goal in this study is to inform the development of more effective interventions, thus helping to alleviate the many adverse outcomes related to drug use. I will talk about the current status of the “gPROSPER” project and describe findings to date. I also will discuss methods in conducting the study—both DNA data collection and analytic challenges
- Prc Seminar April10Th 500Pm
